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Prostate Cancer Mortality

By on April 21, 2013

One-third of men age 65 and older who had prostate specific antigen tests had  higher levels and half were diagnosed with prostate cancer, U.S. researchers  say.

Dr. Louise C. Walter of San Francisco Veterans Affairs Medical Center and  colleagues sought to quantify five-year outcomes following an abnormal PSA  screening result of 4 or more, in older men age 65 and older.

A total of 295,645 men age 65 or older underwent PSA screening in the  Veterans Affairs healthcare system in 2003. They were followed up for five  years.

In total, 25,208 men, or 8.5 percent, had an index PSA level exceeding 4.  During the five-year follow-up period, 8,313 men, or 33 percent, underwent at  least one prostate biopsy and 62.8 percent who underwent prostate biopsy were  diagnosed as having prostate cancer, of whom 82 percent were treated for  prostate cancer.

Performance of prostate biopsy decreased with advancing age and worsening  health, whereas the percentage treated for biopsy-detected cancer exceeded 75  percent even among men age 85 or older, those with a Charlson-Deyo Comorbidity  Index of 3 or higher, and those having low-risk cancer.

Among men with biopsy-detected cancer, the risk of death from non-prostate  cancer causes increased with advancing age and worsening health, the study  said. The findings were published in the journal Internal Medicine.


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