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Peyronie’s Disease

By on August 25, 2013

The precise cause of Peyronie’s Disease remains unknown. But trust us, you don’t want it.

Peyronie’s (pa-ro-NEEZ) disease is the development of fibrous scar tissue inside the penis that causes curved, painful erections.

If you think this applies to you, see a doctor for a physical exam to see if plaque is in the penis. Your doctor will also likely talk to your partner about your sexual relationship. A picture of an erection at home can help your doctor see the severity of the curvature. So don’t be shy.

There are generally two stages of Peyronies disease; acute and chronic.

Neither stage suggests a set length of time, duration or intensity. The acute stage is considered an inflammation phase and is when the most scarring and bending occurs. In some cases the disease is restricted to the acute stage and will resolve itself without treatment. Doctors that witness this generally recommend that the patient wait to see what will happen while others recommend treatment as early and aggressively as possible.

Several factors can contribute to poor wound healing and scar tissue buildup that may play a role in Peyronie’s disease, like:

  • Heredity. If your father or brother has Peyronie’s disease, you have an increased risk of getting the disorder.
  • Connective tissue disorders. Men who have a connective tissue disorder appear to have an increased risk of developing Peyronie’s disease. For example, a number of men who have Peyronie’s disease also have a condition known as Dupuytren’s contracture — a cord-like thickening across the palm that causes the fingers to pull inward.
  • Getting older. The prevalence of Peyronie’s disease increases with age. Age-related changes in tissues may cause them to be more easily injured and less likely to heal well.

Fortunately, there are a number of oral medications available but surgery seems to be most effective according to most reports.

Peyronies-disease-curvatureAccording to the Mayo Clinic website, medications that are used include:

  • Verapamil. This is a drug normally used to treat high blood pressure. It appears to disrupt the production of collagen, a protein that appears to be a key factor in the formation of Peyronie’s disease scar tissue.
  • Interferon. This is a type of protein that appears to disrupt the production of fibrous tissue and help break it down.

Collagenase, an enzyme that breaks down fibrous tissue scar, is currently being studied for treatment of Peyronie’s disease.



Some content for this article provided by Mayoclinic.com


  1. DocGeorge

    December 7, 2014 at 3:18 pm

    One of the side effects of Peyronie’s disease when scar tissue is involved is a loss of sensation in the penis, diminishing one’s enjoyment. Regular use of a quality penis health cream (health professionals recommend Man1 Man Oil) with acetyl L carnitine can help. This ingredient is neuroprotective and helps with peripheral nerve damage to the organ.

  2. DocGeorge

    October 16, 2014 at 9:26 am

    The scar tissue that is often associated with Peyronie’s disease can have the effect of “deadening” the penis, causing a loss of sensation that can have an impact on a man’s sexual satisfaction. One way to address this issue is to utilize a good penis health crème that includes among its ingredients acetyl L carnitine; this is neuroprotective and can help restore penis sensitivity.

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